Real Estate Investment Properties for Sale in Santee, SC

Looking for investment property in Santee, SC with high ROI ?

Explore a variety of short-term homes & houses in Santee, SC. Invest wisely with VRBO & Santee, SC Airbnb properties available for purchase. Find your ideal investment property among our curated listings for a rewarding real estate venture.

Investment Property for Sale in Santee, SC

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PROPERTY	DETAILS	SALE PRICE	INVESTMENT PERFORMANCE
329 Santee Drive Santee, SC Discover the charm of low country living in this stunning waterfront home nestled within t...	4 beds \| 4 baths \| N/A	$569,900	Airbnb cash on cash: N/A Traditional cash on cash: 5.08% Airbnb Rental Income: $null Traditional Rental Income: $3630 Airbnb ROI: N/A Traditional ROI: 5.08%
116 Broad River Dr Santee, SC Amazing waterfront home has just hit the market! 116 Broad River Drive is located in Sant...	4 beds \| 4 baths \| 4,452 sq.ft.	$995,000	Airbnb cash on cash: N/A Traditional cash on cash: 2.23% Airbnb Rental Income: $null Traditional Rental Income: $3604 Airbnb ROI: N/A Traditional ROI: 2.23%
143 Ballard Lane Santee, SC Discover your dream home with this stunning lower-level waterfront condo on Lake Marion! T...	2 beds \| 2 baths \| 1,298 sq.ft.	$225,000	Airbnb cash on cash: 7.88% Traditional cash on cash: 6.54% Airbnb Rental Income: $2752 Traditional Rental Income: $1821 Airbnb ROI: 7.88% Traditional ROI: 6.54%
324 Trillium Ct Santee, SC Beautiful waterfront condo on Lake Marion, the largest lake in South Carolina. Two bedroom...	2 beds \| 2 baths \| 1,328 sq.ft.	$230,000	Airbnb cash on cash: 7.68% Traditional cash on cash: 7.18% Airbnb Rental Income: $2752 Traditional Rental Income: $1996 Airbnb ROI: 7.68% Traditional ROI: 7.18%
433 Santee Dr Santee, SC WOW! Do not let this prime waterfront home in Santee Cooper Resort, a gated waterfront an...	4 beds \| 5 baths \| 3,496 sq.ft.	$1,100,000	Airbnb cash on cash: N/A Traditional cash on cash: 3.36% Airbnb Rental Income: $null Traditional Rental Income: $5137 Airbnb ROI: N/A Traditional ROI: 3.36%
127 William Clark Blvd. Santee, SC As you enter this beautiful home, a welcoming hallway greets you. To the right is a full b...	3 beds \| 3 baths \| 2,482 sq.ft.	$355,000	Airbnb cash on cash: 1.42% Traditional cash on cash: 5.56% Airbnb Rental Income: $1535 Traditional Rental Income: $2469 Airbnb ROI: 1.42% Traditional ROI: 5.56%
106 Broad River Drive Santee, SC PROPOSED CONSTRUCTION on DEEP WATER. Vacant Land/Lot also listed as MLS# 23018200. S...	4 beds \| 3 baths \| N/A	$755,075	Airbnb cash on cash: N/A Traditional cash on cash: 2.43% Airbnb Rental Income: $null Traditional Rental Income: $2903 Airbnb ROI: N/A Traditional ROI: 2.43%
179 William Clark Boulevard Santee, SC This homesite features a private lot with wooded buffer overlooking a golf course. The Sul...	3 beds \| 2 baths \| 1,183 sq.ft.	$259,900	Airbnb cash on cash: 2.5% Traditional cash on cash: 4.85% Airbnb Rental Income: $1535 Traditional Rental Income: $1666 Airbnb ROI: 2.5% Traditional ROI: 4.85%
128 MENDELIN CT Santee, SC	3 beds \| 2 baths \| 1,144 sq.ft.	$180,000	Airbnb cash on cash: 4.25% Traditional cash on cash: 8.08% Airbnb Rental Income: $1535 Traditional Rental Income: $1747 Airbnb ROI: 4.25% Traditional ROI: 8.08%
111 Ballard Lane Santee, SC LAKEFRONT CONDO! Welcome to 111 Ballard Lane on Lake Marion! This lakefront condo has 3 b...	3 beds \| 3 baths \| N/A	$289,000	Airbnb cash on cash: 0.38% Traditional cash on cash: 4.58% Airbnb Rental Income: $1535 Traditional Rental Income: $2232 Airbnb ROI: 0.38% Traditional ROI: 4.58%
130 Par Ct Santee, SC Come take a look at this beautiful home on Santee National Golf Club. It sits on the 16th ...	3 beds \| 3 baths \| 2,800 sq.ft.	$439,000	Airbnb cash on cash: 0.93% Traditional cash on cash: 4.33% Airbnb Rental Income: $1535 Traditional Rental Income: $2487 Airbnb ROI: 0.93% Traditional ROI: 4.33%
409 Santee Drive Santee, SC Located on the big waters of Lake Marion in a protective cove, this waterfront home boast...	4 beds \| 4 baths \| 3,795 sq.ft.	$640,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.31% Airbnb Rental Income: $null Traditional Rental Income: $3602 Airbnb ROI: N/A Traditional ROI: 4.31%
22 Peter Collinson Rd Santee, SC Very nice 2br, 2 full bath home in the Gated Community of Bradford Village in downtown San...	2 beds \| 2 baths \| 1,462 sq.ft.	$239,000	Airbnb cash on cash: 7.33% Traditional cash on cash: 6.76% Airbnb Rental Income: $2752 Traditional Rental Income: $1975 Airbnb ROI: 7.33% Traditional ROI: 6.76%
103 Ballard Lane Santee, SC Lake Marion waterfront 2BR, 2BA condominium in the heart of Santee with close proximity t...	2 beds \| 2 baths \| 1,298 sq.ft.	$218,000	Airbnb cash on cash: 8.17% Traditional cash on cash: 8.65% Airbnb Rental Income: $2752 Traditional Rental Income: $2203 Airbnb ROI: 8.17% Traditional ROI: 8.65%
110 Saluda Drive Santee, SC Discover your dream home in the gated Santee Cooper Resort, a lakefront golf community on ...	4 beds \| 3 baths \| 2,332 sq.ft.	$449,900	Airbnb cash on cash: N/A Traditional cash on cash: 4.62% Airbnb Rental Income: $null Traditional Rental Income: $2606 Airbnb ROI: N/A Traditional ROI: 4.62%
108 Saluda Drive Santee, SC Welcome to your dream home in Santee Cooper Resort on Lake Marion! This new 2,473 sq ft Ju...	4 beds \| 3 baths \| 2,473 sq.ft.	$475,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.27% Airbnb Rental Income: $null Traditional Rental Income: $2687 Airbnb ROI: N/A Traditional ROI: 4.27%
115 Ballard Lane Santee, SC Waterfront STREET LEVEL Condo - NO STAIRS TO CLIMB. 2 bedroom/2 bath condo on Lake Marion...	2 beds \| 2 baths \| 1,298 sq.ft.	$229,000	Airbnb cash on cash: 7.04% Traditional cash on cash: 7.57% Airbnb Rental Income: $2752 Traditional Rental Income: $2218 Airbnb ROI: 7.04% Traditional ROI: 7.57%
108 Wateree Annex Santee, SC Owners had this beautiful home built and has been the only owners. Master bedroom has a v...	3 beds \| 3 baths \| 2,834 sq.ft.	$425,000	Airbnb cash on cash: 1.04% Traditional cash on cash: 4.55% Airbnb Rental Income: $1535 Traditional Rental Income: $2488 Airbnb ROI: 1.04% Traditional ROI: 4.55%
1035 Park Drive Santee, SC Discover this stunning custom-built hm in a serene, established neighborhood, w/its own wo...	2 beds \| 2 baths \| 2,025 sq.ft.	$464,900	Airbnb cash on cash: 3.35% Traditional cash on cash: 3.59% Airbnb Rental Income: $2752 Traditional Rental Income: $2209 Airbnb ROI: 3.35% Traditional ROI: 3.59%
312 Wactor Santee, SC Smuge ( the cat) Says Welcome HOME! This beautifully remodeled 3-bedroom, 2-bathroom home ...	3 beds \| 2 baths \| 2,140 sq.ft.	$405,000	Airbnb cash on cash: 1.06% Traditional cash on cash: 4.03% Airbnb Rental Income: $1535 Traditional Rental Income: $2217 Airbnb ROI: 1.06% Traditional ROI: 4.03%
317 Parklane Drive Santee, SC This lovely brick home features 3 bedrooms and 2 bathrooms with plenty of storage and larg...	3 beds \| 2 baths \| 2,296 sq.ft.	$379,999	Airbnb cash on cash: 1.61% Traditional cash on cash: 4.76% Airbnb Rental Income: $1535 Traditional Rental Income: $2214 Airbnb ROI: 1.61% Traditional ROI: 4.76%
119 Ballard Lane Santee, SC This is truly the most amazing property in Ballards Point II and you will love it at first...	3 beds \| 3 baths \| 1,689 sq.ft.	$298,500	Airbnb cash on cash: 1.96% Traditional cash on cash: 6.01% Airbnb Rental Income: $1535 Traditional Rental Income: $2228 Airbnb ROI: 1.96% Traditional ROI: 6.01%
222 Cooper Drive Santee, SC This amazing custom-built Mediterranean style home sits on two lots in Santee Cooper Resor...	3 beds \| 4 baths \| 3,800 sq.ft.	$539,500	Airbnb cash on cash: 0.67% Traditional cash on cash: 4.4% Airbnb Rental Income: $1535 Traditional Rental Income: $2972 Airbnb ROI: 0.67% Traditional ROI: 4.4%
209 Myrtlewood Dr Santee, SC Golf course home in Chapel Creek subdivision and Santee National Golf Club, overlooks the ...	3 beds \| 2 baths \| 2,268 sq.ft.	$358,000	Airbnb cash on cash: 1.31% Traditional cash on cash: 4.65% Airbnb Rental Income: $1535 Traditional Rental Income: $2213 Airbnb ROI: 1.31% Traditional ROI: 4.65%
127 Saluda Dr Santee, SC Beautiful ranch golf course home located in Santee Cooper Resort on the shores of Lake Mar...	4 beds \| 3 baths \| 2,777 sq.ft.	$499,000	Airbnb cash on cash: N/A Traditional cash on cash: 4.78% Airbnb Rental Income: $null Traditional Rental Income: $2901 Airbnb ROI: N/A Traditional ROI: 4.78%
116 Williams Clark Boulevard Santee, SC Welcome to your new home in the heart of Santee's Center Pointe community! This 2022-built...	4 beds \| 2 baths \| N/A	$315,000	Airbnb cash on cash: N/A Traditional cash on cash: 6.02% Airbnb Rental Income: $null Traditional Rental Income: $2235 Airbnb ROI: N/A Traditional ROI: 6.02%
111 Cooper Circle Santee, SC Welcome to your custom-built dream home, where elegance meets functionality in a picturesq...	4 beds \| 3 baths \| 2,679 sq.ft.	$557,999	Airbnb cash on cash: N/A Traditional cash on cash: 3.36% Airbnb Rental Income: $null Traditional Rental Income: $2518 Airbnb ROI: N/A Traditional ROI: 3.36%

Real Estate investment in Santee, SC

There are 28 properties for sale in the city of Santee . The median list price in Santee is $415,000 and the average price per square foot is $179. In January 2025, the average monthly cash on cash return in Santee is 5.00%. The average monthly rental income in Santee is $2,234.

Santee, SC Real Estate Investing: FAQs for Buyers, Sellers and Investors

There are 28 investment properties available for sale in Santee.

In 2025, the best neighborhood to buy investment property is Santee.

The ROI for Long-Term is higher than the Short-Term in Santee with average rental income of $2,234.

Your search for investment property begins and ends here

Investment Property for Sale in Santee, SC

329 Santee Drive

Santee, SC

4 beds | 4 baths | N/A

$569,900

Airbnb cash on cash: N/A

Traditional cash on cash: 5.08%

Airbnb Rental Income: $null

Traditional Rental Income: $3630

Airbnb ROI: N/A

Traditional ROI: 5.08%

116 Broad River Dr

Santee, SC

4 beds | 4 baths | 4,452 sq.ft.

$995,000

Airbnb cash on cash: N/A

Traditional cash on cash: 2.23%

Airbnb Rental Income: $null

Traditional Rental Income: $3604

Airbnb ROI: N/A

Traditional ROI: 2.23%

143 Ballard Lane

Santee, SC

2 beds | 2 baths | 1,298 sq.ft.

$225,000

Airbnb cash on cash: 7.88%

Traditional cash on cash: 6.54%

Airbnb Rental Income: $2752

Traditional Rental Income: $1821

Airbnb ROI: 7.88%

Traditional ROI: 6.54%

324 Trillium Ct

Santee, SC

2 beds | 2 baths | 1,328 sq.ft.

$230,000

Airbnb cash on cash: 7.68%

Traditional cash on cash: 7.18%

Airbnb Rental Income: $2752

Traditional Rental Income: $1996

Airbnb ROI: 7.68%

Traditional ROI: 7.18%

433 Santee Dr

Santee, SC

4 beds | 5 baths | 3,496 sq.ft.

$1,100,000

Airbnb cash on cash: N/A

Traditional cash on cash: 3.36%

Airbnb Rental Income: $null

Traditional Rental Income: $5137

Airbnb ROI: N/A

Traditional ROI: 3.36%

127 William Clark Blvd.

Santee, SC

3 beds | 3 baths | 2,482 sq.ft.

$355,000

Airbnb cash on cash: 1.42%

Traditional cash on cash: 5.56%

Airbnb Rental Income: $1535

Traditional Rental Income: $2469

Airbnb ROI: 1.42%

Traditional ROI: 5.56%

106 Broad River Drive

Santee, SC

4 beds | 3 baths | N/A

$755,075

Airbnb cash on cash: N/A

Traditional cash on cash: 2.43%

Airbnb Rental Income: $null

Traditional Rental Income: $2903

Airbnb ROI: N/A

Traditional ROI: 2.43%

179 William Clark Boulevard

Santee, SC

3 beds | 2 baths | 1,183 sq.ft.

$259,900

Airbnb cash on cash: 2.5%

Traditional cash on cash: 4.85%

Airbnb Rental Income: $1535

Traditional Rental Income: $1666

Airbnb ROI: 2.5%